Revisiting the 1986 Molecular Cloning of Interleukin 6
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چکیده
منابع مشابه
Revisiting the 1986 Molecular Cloning of Interleukin 6
We reported molecular cloning of B cell stimulatory factor-2 (BSF-2)/interleukin 6 (IL-6) in 1986 (1), the same year that IL-4 and IL-5 were cloned (2, 3). Prior to the publication of our article (1), it was known that antigenic stimulation induced growth and differentiation of B lymphocytes into antibody forming plasma cells with the help of T lymphocytes and this function of T lymphocytes cou...
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Murine interleukin-5 (IL-5) is known to play an essential role in Ig production of B cells and proliferation and differentiation of eosinophils. Here, we have isolated cDNA clones encoding a murine IL-5 receptor by expression screening of a library prepared from a murine IL-5 dependent early B cell line. A cDNA library was expressed in COS7 cells and screened by panning with the use of anti-IL-...
متن کاملMolecular cloning of cDNA for the human interleukin-2 receptor.
Interleukin-2 (IL-2 or T cell growth factor) is a 14,500 daltons glycoprotein critically involved in the development of a normal human immune response [1, 2J. Recently, cDNA for this lymphokine has been isolated and expressed in both prokaryotic and eukaryotic cells [3-5J. Further, the human IL-2 gene has been cloned, sequenced [6], and localized to chromosome 4. As with other polypeptide hormo...
متن کاملRevisiting the Identification and cDNA Cloning of T Cell-Replacing Factor/Interleukin-5
This is a perspective based on the paper "Cloning of complementary DNA encoding T cell-replacing factor and identity with B cell growth factor II," by Kinashi et al. (1). We have been interested in understanding the molecular basis of T-B cell cooperation for antibody formation. Although many investigators had described a number of different soluble factors that appeared to have biological rele...
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Background and Objective: Preterm birth occurs in 8% to 11% of all pregnancies and is responsible for 75% to 80% of all neonatal deaths. Cytokines may be involved in the etiology of preterm birth through their stimulation of prostaglandin synthesis. Cytokines may be released intocervicovaginal fluid during the breakdown of the chorio-decidual adhesion or from an inflammatory reactio...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2014
ISSN: 1664-3224
DOI: 10.3389/fimmu.2014.00456